Abstract #3980
Quantitative Gd-DOTA-based Aerosol Deposition in Asthmatic and Emphysematous Rats using UTE-MRI
Hongchen Wang 1 , Catherine Sebri 1 , Sbastien Jud 2 , Anne Maurin 2 , Stphanie Rtif 3 , Marilyne Le Me 3 , Rose-Marie Dubuisson 1 , Georges Willoquet 1 , Khaoula Bouazizi-Verdier 1 , Luc Darrasse 1 , Genevive Guillot 1 , Xavier Matre 1 , and Ludovic de Rochefort 1
1
Imagerie par Rsonance Magntique Mdicale
et Multi-Modalits (UMR8081) IR4M, CNRS, Univ.
Paris-Sud, Orsay, France,
2
Centre
de Recherches Biologiques CERB, Baugy, France,
3
Centre
d'Imagerie du Petit Animal CIPA, CNRS-TAAM UPS44,
Orlans, France
Asthma and emphysema are chronic respiratory diseases,
which are commonly treated by inhalation of nebulized
drugs. Aerosol deposition patterns are difficult to
predict as they highly depend on airway geometry,
breathing parameters, aerosol and gas properties. In
vitro and in vivo studies have been performed to better
understand deposition mechanisms and to improve inhaled
drug delivery. Here, 3D UTE-MRI combined with
spontaneous nose-only inhalation of aerosolized Gd-DOTA
was implemented at 1.5T to map the distribution of
aerosol deposition and to characterize the aerosol lung
clearance in asthmatic and emphysematous rats. This
functional lung imaging may be transferred to the
clinic.
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