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Abstract #3980

Quantitative Gd-DOTA-based Aerosol Deposition in Asthmatic and Emphysematous Rats using UTE-MRI

Hongchen Wang 1 , Catherine Sebri 1 , Sbastien Jud 2 , Anne Maurin 2 , Stphanie Rtif 3 , Marilyne Le Me 3 , Rose-Marie Dubuisson 1 , Georges Willoquet 1 , Khaoula Bouazizi-Verdier 1 , Luc Darrasse 1 , Genevive Guillot 1 , Xavier Matre 1 , and Ludovic de Rochefort 1

1 Imagerie par Rsonance Magntique Mdicale et Multi-Modalits (UMR8081) IR4M, CNRS, Univ. Paris-Sud, Orsay, France, 2 Centre de Recherches Biologiques CERB, Baugy, France, 3 Centre d'Imagerie du Petit Animal CIPA, CNRS-TAAM UPS44, Orlans, France

Asthma and emphysema are chronic respiratory diseases, which are commonly treated by inhalation of nebulized drugs. Aerosol deposition patterns are difficult to predict as they highly depend on airway geometry, breathing parameters, aerosol and gas properties. In vitro and in vivo studies have been performed to better understand deposition mechanisms and to improve inhaled drug delivery. Here, 3D UTE-MRI combined with spontaneous nose-only inhalation of aerosolized Gd-DOTA was implemented at 1.5T to map the distribution of aerosol deposition and to characterize the aerosol lung clearance in asthmatic and emphysematous rats. This functional lung imaging may be transferred to the clinic.

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