Evaluation of b-value distributions for monoexponential model of prostate cancer diffusion-weighted imaging using b values up to 2000 s/mm 2 : a repeatability study on region of interest level
Harri Merisaari 1 , Jussi Toivonen 2 , Marko Pesola 3 , Pekka Taimen 4 , Peter J Bostrm 5 , Tapio Pahikkala 2 , Hannu J Aronen 3 , and Ivan Jambor 3
Turku PET Centre, University of Turku,
of Information Technology, University of Turku, Turku,
of Diagnostic Radiology, University of Turku, Turku,
of Pathology, Turku University Hospital, Turku, Finland,
of Urology, Turku University Hospital, Turku, Finland
We elevated the effect of 4083 different b-value
combinations on the prostate cancer detection, Gleason
score prediction, and repeatability of monoexponential
model for diffusion weighted imaging (DWI) using
b-values up to 2000 s/mm
. Fifty patients
with histologically confirmed PCa underwent two repeated
3T MRI examinations before radical prostatectomy. DWI
was performed using 12 equally distributed b-values.
B-value distributions containing only b values in end of
the b-value range (~1500 to 2000 s/mm
demonstrated the lowest diagnostic performance and
repeatability while the rest of b values distributions
had similar performance and repeatability.
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