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Abstract #4001

Evaluation of b-value distributions for monoexponential model of prostate cancer diffusion-weighted imaging using b values up to 2000 s/mm 2 : a repeatability study on region of interest level

Harri Merisaari 1 , Jussi Toivonen 2 , Marko Pesola 3 , Pekka Taimen 4 , Peter J Bostrm 5 , Tapio Pahikkala 2 , Hannu J Aronen 3 , and Ivan Jambor 3

1 Turku PET Centre, University of Turku, Turku, Finland, 2 Department of Information Technology, University of Turku, Turku, Finland, 3 Department of Diagnostic Radiology, University of Turku, Turku, Finland, 4 Department of Pathology, Turku University Hospital, Turku, Finland, 5 Department of Urology, Turku University Hospital, Turku, Finland

We elevated the effect of 4083 different b-value combinations on the prostate cancer detection, Gleason score prediction, and repeatability of monoexponential model for diffusion weighted imaging (DWI) using b-values up to 2000 s/mm 2 . Fifty patients with histologically confirmed PCa underwent two repeated 3T MRI examinations before radical prostatectomy. DWI was performed using 12 equally distributed b-values. B-value distributions containing only b values in end of the b-value range (~1500 to 2000 s/mm 2 ) demonstrated the lowest diagnostic performance and repeatability while the rest of b values distributions had similar performance and repeatability.

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