Quantitative BOLD imaging at 3T: Temporal changes within hepatocellular carcinoma following oxygen challenge
Andrew J Patterson 1 , Andrew N Priest 1 , David J Bowden 1 , Martin J Graves 1 , and David J Lomas 1
Department of Radiology, Addenbrooke's
Hospital & University of Cambridge, Cambridge, England,
A number of studies have investigated Blood Oxygen Level
Dependent (BOLD) contrast changes in measuring
perturbations in oxygenation within neoplasms. The
purpose of this study is to investigate the utility of
oxygen to induce temporal changes in T2* in
hepatocellular carcinoma (HCC) patients (n=10) with a
background of diffuse liver disease. An elevated BOLD
signal was noted in HCC and in diffuse liver disease.
These findings were not observed in a healthy volunteer
cohort (n=11). These study results suggest fibrosis as
well as neoplasmic changes can result in measurable BOLD
signal intensity response to hyperoxic stimuli.
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