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Abstract #4004

Quantitative BOLD imaging at 3T: Temporal changes within hepatocellular carcinoma following oxygen challenge

Andrew J Patterson 1 , Andrew N Priest 1 , David J Bowden 1 , Martin J Graves 1 , and David J Lomas 1

1 Department of Radiology, Addenbrooke's Hospital & University of Cambridge, Cambridge, England, United Kingdom

A number of studies have investigated Blood Oxygen Level Dependent (BOLD) contrast changes in measuring perturbations in oxygenation within neoplasms. The purpose of this study is to investigate the utility of oxygen to induce temporal changes in T2* in hepatocellular carcinoma (HCC) patients (n=10) with a background of diffuse liver disease. An elevated BOLD signal was noted in HCC and in diffuse liver disease. These findings were not observed in a healthy volunteer cohort (n=11). These study results suggest fibrosis as well as neoplasmic changes can result in measurable BOLD signal intensity response to hyperoxic stimuli.

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