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Abstract #4017

Assessment of Diabetic Nephropathy in Mouse Models: GlucoCEST

Feng Wang 1,2 , David Kopylov 3 , Zhongliang Zu 1,2 , Keiko Takahashi 4,5 , John C. Gore 1,2 , Raymond C. Harris 4,5 , Takamune Takahashi 4,5 , and C. Chad Quarles 1,2

1 Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN, United States, 2 Institute of Imaging Sciences, Vanderbilt University, TN, United States, 3 Drexel University, PA, United States, 4 Vanderbilt O'Brien Mouse Kidney Physiology and Disease Center, Vanderbilt University, TN, United States, 5 Division of Nephrology and Hypertension, Vanderbilt University, TN, United States

Mouse models of diabetes (e.g. regular db/m, moderate type II diabetic db/db and advanced diabetic db/db eNOS-/-) provide especially valuable opportunities for evaluating the role of quantitative MRI as biomarkers of renal nephropathy. Diabetic nephropathy is associated with the changes in tissue metabolites (e.g. glucose, glycogen, glycosaminoglycan) that exhibit significant chemical exchange saturation transfer (CEST) effects in MRI. Here we applied CEST imaging at 7T to differentiate moderate and advanced diabetic kidney disease. The sensitivity of glucoCEST in assessing the progress of diabetic kidney disease was evaluated.

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