Abstract #4017
Assessment of Diabetic Nephropathy in Mouse Models: GlucoCEST
Feng Wang 1,2 , David Kopylov 3 , Zhongliang Zu 1,2 , Keiko Takahashi 4,5 , John C. Gore 1,2 , Raymond C. Harris 4,5 , Takamune Takahashi 4,5 , and C. Chad Quarles 1,2
1
Radiology and Radiological Sciences,
Vanderbilt University, Nashville, TN, United States,
2
Institute
of Imaging Sciences, Vanderbilt University, TN, United
States,
3
Drexel
University, PA, United States,
4
Vanderbilt
O'Brien Mouse Kidney Physiology and Disease Center,
Vanderbilt University, TN, United States,
5
Division
of Nephrology and Hypertension, Vanderbilt University,
TN, United States
Mouse models of diabetes (e.g. regular db/m, moderate
type II diabetic db/db and advanced diabetic db/db eNOS-/-)
provide especially valuable opportunities for evaluating
the role of quantitative MRI as biomarkers of renal
nephropathy. Diabetic nephropathy is associated with the
changes in tissue metabolites (e.g. glucose, glycogen,
glycosaminoglycan) that exhibit significant chemical
exchange saturation transfer (CEST) effects in MRI. Here
we applied CEST imaging at 7T to differentiate moderate
and advanced diabetic kidney disease. The sensitivity of
glucoCEST in assessing the progress of diabetic kidney
disease was evaluated.
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