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Abstract #4020

Optimizing dose and imaging parameters in MR renography for quantitative measurement of renal function

Jeff L Zhang 1 , Christopher C Conlin 1 , Kristi Carlston 1 , Daniel Kim 1 , Glen Morrell 1 , Kathryn Morton 1 , and Vivian S Lee 1

1 Radiology, University of Utah, Salt Lake City, Utah, United States

Conventional measures of renal function, such as serum Cr, are insensitive to renal disease, particularly when only a single kidney is affected. Many have advocated low-dose MR renography, to measure renal function noninvasively. In this study we systematically analyzed how the accuracy of tracer kinetic models to analyze MR renography data depends on injected Gd dose and on image acquisition parameters, such as TI in SR sequence. Following a Monte Carlo simulation, we compared renal function estimates using different protocols in 22 patients.

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