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Abstract #4023

MRI- R2* Relaxometry for assessment of kidney iron accumulation as a cause of renal dysfunction in patients with sickle cell disease (SCD)

Sarah Keller 1 , Bjoern Schoennagel 1 , Zhiyue Jerry Wang 2 , Regine Grosse 3 , Peter Nielsen 4 , Gerhard Adam 1 , Roland Fischer 1 , and Jin Yamamura 1

1 Diagnostic and Interventional Radiology, University Medicine Hamburg Eppendorf, Hamburg, Germany, 2 Radiology, Children's Medical Center Dallas, Dallas, Texas, United States, 3 Pediatric Hematology and Oncology, University Medicine Hamburg Eppendorf, Hamburg, Germany, 4 Institute of Biochemistry and Molecular Biology, Center of Experimental Medicine, Hamburg, Germany

Renal iron accumulation leading to renal dysfunction and impairment may be an underestimated factor during disease course of transfusion dependent haematological diseases like Hereditary Hemochromatosis (HHC), Sickle Cell Disease (SCD) and Transfusion dependent Thalasemia (TDT). R2* -MRI and biomagnetic liver susceptometry (SQUID-BLS) was applied to estimate cortical and medullary renal and liver iron content. Correlation analysis of iron accumulation and laboratory findings (lactate dehydrogenase, bilirubin) was performed to estimate organ involvement.

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