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Abstract #4032

Gradient Echo Signal Decays in Gynecological Cancers Require a Gaussian Augmentation of the Mono-Exponential (GAME) Model: Preliminary Evaluation Post External Beam Radiation Therapy at 3T

Pelin Aksit Ciris 1,2 , Robert V. Mulkern 2,3 , Mukund Balasubramanian 2,3 , Antonio L. Damato 2,4 , Ravi T. Seethamraju 5 , Janice Fairhurst 1 , Ferenc A. Jolesz 1,2 , Clare M. Tempany-Afdhal 1,2 , Ehud Schmidt 1,2 , and Akila N. Viswanathan 2,4

1 Brigham and Women's Hospital, Boston, MA, United States, 2 Harvard Medical School, Boston, MA, United States, 3 Boston Children's Hospital, Boston, MA, United States, 4 Dana-Farber Cancer Institute, Boston, MA, United States, 5 Siemens Healthcare, MA, United States

Tumor hypoxia increases treatment resistance and metastatic potential. MRI attempts to detect hypoxia in cervical cancer via R2* using multiple-gradient-echo (GRE) signals with a standard Mono-Exponential (ME) decay model were reported. We have evaluated this in gynecologic cancers post External-Beam-Radiation-Therapy (EBRT), and report that proper characterization of GRE signals requires a Gaussian Augmentation of the Mono-Exponential (GAME) decay model. GAME improves characterization significantly (p<0.05) in 25% of all tumor regions, and highly significantly (p<0.005) in 15% of all tumor regions, which improves the potential for finding biomarkers of e.g. oxygenation status, with potential to improve targeting of radiation treatment.

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