Advanced Cervical Cancer: Quantitative Assessment of Early Response with Intravoxel Incoherent Motion Diffusion-weighted Magnetic Resonance Imaging after Neoadjuvant Chemotherapy
Yanchun Wang 1 and Daoyu Hu 1
Tongji Hospital Tongji Medical College,
Wuhan, Hubei, China
Nowadays, Neoadjuvant chemotherapy (NACT) of cervical
cancer is widely employed in clinical. The aim of NACT
is to reducing the tumor size and eliminating
latent/micro lymph node metastases or improving
radiation sensitivity before surgery or radiotherapy.
Unfortunately, the cancer progressed in some patients
and the responded rate of NACT in cervical cancer only
ranges from 65% to 87.5% . Non-responded NACT may
increase the risk of tumor progression and surgical
difficulty, and the response to NACT can be considered
as an independent prognostic factor . When non-responded
NACT occurs by RECISTs, modifying the treatment strategy
has to be considered, including earlier surgery or
radiation therapy . It does really need good early
predictors to evaluate NACT respondents before RECISTs.
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