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Abstract #4106

Intra-individual crossover comparison of dose of gadoxetic acid for liver MRI: Parameter optimization and quantitative relaxometry in normal volunteers

Utaroh Motosugi 1,2 , Peter Bannas 1,3 , Diego Hernando 1 , Mahdi Salmani Rahimi 4,5 , James H. Holmes 6 , and Scott B. Reeder 1,7

1 Radiology, University of Wisconsin, Madison, Wisconsin, United States, 2 Radiology, University of Yamanashi, Chuo-shi, Yamanashi, Japan, 3 Radiology, University Hospital Hamburg-Eppendorf, Humburg, Germany, 4 Biomedical Engineering, University of Wisconsin, Madison, Wisconsin, United States, 5 Radiology, Stanford University, Stanford, Calfornia, United States, 6 5Global MR Applications and Workflow, GE Healthcare, Madison, Wisconsin, United States, 7 Medical Physics, University of Wisconsin, Madison, Wisconsin, United States

Gadoxetic acid is a hepatobiliary contrast agent with important clinical applications. However, the approved dose (0.025mmol/kg) is 1/4 that of traditional MR contrast agents, that may result in insuf´Čücient contrast especially for dynamic phase imaging. For this reason, many institutions have adopted the use of higher doses as a clinical standard. This motivated a systematic evaluation of higher dosing of gadoxetic acid with relaxometry. In this study, we show that 0.05mmol/kg gadoxetic acid leads to significantly higher SNR and CNR performance than 0.025mmol/kg. Further, a 10-minute delay may be feasible for hepatobiliary-phase imaging when using 0.05mmol/kg of gadoxetic acid.

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