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Abstract #4125

Diffusion-weighted magnetic resonance imaging for the prediction of response to neoadjuvant chemoradiotherapy in esophageal cancer.

Peter S.N. van Rossum 1,2 , Astrid L.H.M.W. van Lier 1 , Marco van Vulpen 1 , Onne Reerink 1 , Steven H. Lin 3 , Richard van Hillegersberg 2 , Jelle P. Ruurda 2 , Gert J. Meijer 1 , and Irene M. Lips 1

1 Department of Radiotherapy, University Medical Center Utrecht, Utrecht, Netherlands, 2 Department of Surgery, University Medical Center Utrecht, Utrecht, Netherlands, 3 Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States

This study aimed to explore the value of diffusion-weighted magnetic resonance imaging (DW-MRI) for the prediction of response to neoadjuvant chemoradiotherapy (nCRT) in esophageal cancer. In 20 patients receiving nCRT for esophageal cancer DW-MRI scanning was performed before nCRT, after 8-13 fractions, and before surgery. The median tumor apparent diffusion coefficient (ADC) was determined at these three time points. The predictive potential of initial tumor ADC, and change in ADC (ΔADC) during and after treatment for pathologic complete response (pathCR) was assessed. The treatment-induced change in ADC during the first 2-3 weeks of nCRT (ΔADCduring) was highly predictive for pathCR.

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