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Abstract #4134

Accelerated 4D MRI for investigating release and dispersion of an ingested drug model inside the human stomach

Vlad Ceregan 1 , Jelena Curcic 1,2 , Sebastian Kozerke 1 , and Andreas Steingoetter 1,2

1 Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland, 2 Division of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland

The assessment of intragastric perfromance of therapeutic agents is of main importance for effective drug delivery design. This work takes a first step in this direction by proposing a MRI method for 4D monitoring of the release and distribution of a drug model from a standard hard gelatine capsule within the human stomach. The results show that accelerated 4D MRI is feasible in visualizing release and dispersion of an ingested drug model at temporal resolutions of up to 1 second.

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