Abstract #4134
Accelerated 4D MRI for investigating release and dispersion of an ingested drug model inside the human stomach
Vlad Ceregan 1 , Jelena Curcic 1,2 , Sebastian Kozerke 1 , and Andreas Steingoetter 1,2
1
Institute for Biomedical Engineering,
University and ETH Zurich, Zurich, Switzerland,
2
Division
of Gastroenterology and Hepatology, University Hospital
Zurich, Zurich, Switzerland
The assessment of intragastric perfromance of
therapeutic agents is of main importance for effective
drug delivery design. This work takes a first step in
this direction by proposing a MRI method for 4D
monitoring of the release and distribution of a drug
model from a standard hard gelatine capsule within the
human stomach. The results show that accelerated 4D MRI
is feasible in visualizing release and dispersion of an
ingested drug model at temporal resolutions of up to 1
second.
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