Abstract #4176
T2, dGEMRIC and gagCEST Cartilage Assessment in an in Vivo OA Canine Model
Maria I Menendez 1 , Daniel Clark 1 , Bianca Hettlich 1 , and Michael Knopp 1
1
The Ohio State University, Columbus, Ohio,
United States
The purpose of this study was to use T2, dGEMRIC and
gagCEST to serially evaluate articular cartilage in an
in vivo ACL OA canine model. T2 was higher in the ACL
transected knee. At T2 was higher than baseline. Lower
T1 was found in the ACL versus control at 12 weeks. For
ACL knees, lower T1 at 6 and 12 weeks than baseline.
MTRasym was not statistically significant between
control and ACL knees, neither among timelines. T2 and
dGEMRIC correlated moderately negative. This study
showed that T2 and dGEMRIC serially evaluated cartilage
in an ACL OA canine model.
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