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Abstract #4176

T2, dGEMRIC and gagCEST Cartilage Assessment in an in Vivo OA Canine Model

Maria I Menendez 1 , Daniel Clark 1 , Bianca Hettlich 1 , and Michael Knopp 1

1 The Ohio State University, Columbus, Ohio, United States

The purpose of this study was to use T2, dGEMRIC and gagCEST to serially evaluate articular cartilage in an in vivo ACL OA canine model. T2 was higher in the ACL transected knee. At T2 was higher than baseline. Lower T1 was found in the ACL versus control at 12 weeks. For ACL knees, lower T1 at 6 and 12 weeks than baseline. MTRasym was not statistically significant between control and ACL knees, neither among timelines. T2 and dGEMRIC correlated moderately negative. This study showed that T2 and dGEMRIC serially evaluated cartilage in an ACL OA canine model.

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