Abstract #4182
Cluster Analysis for T 2 and T 1rho Relaxation Times using 3D Projection Maps of the Femoral Condyle in a Healthy and ACL-injured Population
Uchechukwuka Diana Monu 1,2 , Brian A Hargreaves 1,2 , Caroline D Jordan 2,3 , Garry E Gold 2,3 , and Emily J McWalter 2
1
Electrical Engineering, Stanford University,
Stanford, California, United States,
2
Radiology,
Stanford University, Stanford, California, United
States,
3
Bioegineering, Stanford University,
Stanford, California, United States
Osteoarthritis (OA) is a heterogeneous and
multifactorial joint disease that is characterized by
morphological, biochemical and structural changes to the
cartilage. The etiology and progression of the disease
remains largely uncertain making disease modifying
treatments challenging. This works uses parametric MRI
modeling and a 3D visualization technique to track
clusters of elevated T2 and T1rho relaxation times in an
ACL-injured population. Results show the potential for
cluster analysis to identify and quantify focal defects
in cartilage over time. This may provide a useful
biomarker for tracking early cartilage degeneration.
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