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Abstract #4194

Relaxation time constants T1 and T2* of bound and free water in cortical bone at 600 MHz and 700 MHz.

Bainan Wu 1 , Robert Nikolov 2 , Hongda Shao 2 , Jun Chen 2 , Graeme Bydder 2 , Maurizio Pellecchia 1 , and Jiang Du 2

1 Sanford-Burnham Medical Research Institute, La Jolla, California, United States, 2 Radiology, University of California, San Diego, San Diego, California, United States

The purpose of this study is to measure and report the field dependence of NMR relaxation times (T* and T1) of the free and bound water in cortical bone at magnetic field strenghts corresponding to frequencies of 600 MHz and 700MHz. T2* of bound/free water is measured to be 6.2(0.1)s /80(3)s at 600MHz and decreases to 5.4(0.1)s /63(5)s at 700 MHz. T1 of bound/free water is reported to be 628/632ms at 600 MHz and 661/672 ms at 700 MHz. At both field strengths, the free water contributes to about 10% of the NMR signal.

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