Abstract #4203
Characterizing the Blood Oxygen Level-Dependent Fluctuation in Musculoskeletal Tumors Using Functional Magnetic Resonance Imaging
Li-Sha Duan 1 , Meng-Jun Wang 1 , Feng Sun 1 , Zhen-Jiang Zhao 1 , Mei Xing 1 , Yu-Feng Zang 2 , Steven Louis 3 , Sheng-Jie Cui 4 , Han Zhang 2 , and Jianling Cui 1
1
Department of Radiology, The Third Hospital
of Hebei Medical University, Shijiazhuang, Hebei, China,
2
Center
for Cognition and Brain Disorders and the Affiliated
Hospital, Hangzhou Normal University, Hangzhou,
Zhejiang, China,
3
Physics
Department, Oakland University, Rochester, Michigan,
United States,
4
Department of Anatomy and Cell
Biology, Wayne State University School of Medicine, East
Canfield Avenue, Detroit, United States
Fifty-two patients with MSK tumors were examined using
1.5 T MR scanner with EPI BOLD. The BOLD time series in
each ROI was transformed from temporal to frequency
domain with a fast Fourier transformation. This power
spectrum was then divided into four frequency bands. In
the frequency band between 0.073 and 0.198 Hz, the BOLD
fluctuations were stronger in the periphery than that in
the center of malignant MSK tumors; however, no such a
difference was observed for the benign tumors, which may
provide the first evidence that BOLD fMRI could be
utilized to delineate vascularization characteristics in
MSK tumors.
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