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Abstract #4203

Characterizing the Blood Oxygen Level-Dependent Fluctuation in Musculoskeletal Tumors Using Functional Magnetic Resonance Imaging

Li-Sha Duan 1 , Meng-Jun Wang 1 , Feng Sun 1 , Zhen-Jiang Zhao 1 , Mei Xing 1 , Yu-Feng Zang 2 , Steven Louis 3 , Sheng-Jie Cui 4 , Han Zhang 2 , and Jianling Cui 1

1 Department of Radiology, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, China, 2 Center for Cognition and Brain Disorders and the Affiliated Hospital, Hangzhou Normal University, Hangzhou, Zhejiang, China, 3 Physics Department, Oakland University, Rochester, Michigan, United States, 4 Department of Anatomy and Cell Biology, Wayne State University School of Medicine, East Canfield Avenue, Detroit, United States

Fifty-two patients with MSK tumors were examined using 1.5 T MR scanner with EPI BOLD. The BOLD time series in each ROI was transformed from temporal to frequency domain with a fast Fourier transformation. This power spectrum was then divided into four frequency bands. In the frequency band between 0.073 and 0.198 Hz, the BOLD fluctuations were stronger in the periphery than that in the center of malignant MSK tumors; however, no such a difference was observed for the benign tumors, which may provide the first evidence that BOLD fMRI could be utilized to delineate vascularization characteristics in MSK tumors.

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