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Abstract #4210

Using the Ratio of T1ρ and T2 MR Parameters to Examine the Relationship Between Anterior Cruciate Ligament (ACL) Abnormalities and Patellofemoral Cartilage Integrity

Nathaniel E. Calixto 1 , Lorenzo Nardo 1 , Deepak Kumar 2 , Richard B. Souza 1 , Xiaojuan Li 1 , Thomas M. Link 1 , and Sharmila Majumdar 1

1 Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California, United States, 2 Division of Physical Therapy, College of Health Professions, Medical University of South Carolina, Charleston, South Carolina, United States

While T1ρ and T2 MR relaxation times have become established metrics for cartilage assessment, the T1ρ/T2 ratio could eliminate hydration effects and better represent macromolecular integrity. A lowered T1ρ/T2 ratio in patellofemoral cartilage was associated with ACL lesions, consistent with the relationship between ACL pathology and patellofemoral osteoarthritis. In subjects with healthy patellofemoral cartilage, significant T1ρ/T2 ratio differences were observed between those with and without ACL lesions; no significant differences were observed with T1ρ or T2 individually, suggesting heightened sensitivity of the T1ρ/T2 ratio. Future work is necessary to verify the applicability of the T1ρ/T2 ratio in other anatomy.

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