Abstract #4222
Evaluation of the glycosaminoglycan content in healthy and degenerated menisci with gagCEST at 3T
Benedikt Hager 1 , Vladimir Juras 1,2 , Olgica Zaric 1 , Vladimir Mlynarik 1 , Stefan Zbyn 1 , Pavol Szomolanyi 1,2 , and Siegfried Trattnig 1
1
High Field MR Centre, Department of
Biomedical Imaging and Image-guided Therapy, Medical
University of Vienna, Vienna, Austria,
2
Department
of Imaging Methods, Institute of Measurement Science,
Slovak Academy of Sciences, Dubravska cesta 9,
Bratislava, Slovakia
The purpose of this study was to demonstrate the
feasibility of Glycosaminoglycan Chemical Exchange
Saturation Transfer (gagCEST) imaging for the detection
of degenerated menisci. The results show that the
average of asymmetries in gagCEST z-spectra summed over
all offsets from 0.6 to 1.8 ppm was significantly lower
(p < 0.02) in degenerated meniscal horns (2.2 5.5 %)
compared to healthy meniscal horns (8.4 3.9%), which
indicates a decrease in GAG content in the degenerated
menisci. This study demonstrates that gagCEST imaging
holds great potential as a biomarker to differentiate
between healthy and degenerated menisci.
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