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Abstract #4231

An improved saturation scheme for measuring gagCEST in human knee at 7 T

Vladimir Mlynarik 1 , Stefan Zbyn 1 , Vladimir Juras 1 , Pavol Szomolanyi 1 , Martin Brix 1 , Benjamin Schmitt 2 , and Siegfried Trattnig 1

1 High Field MR Center, Medical University of Vienna, Vienna, Austria, 2 Siemens Ltd, Macquarie Park, Australia

Application of the gagCEST mapping technique on human knee is complicated by technical limitations of scanners, safety regulations and by an inhomogeneous B 0 field over the knee cartilage. Measurements on human volunteers using either Gaussian or adiabatic full passage hs2 saturation pulses showed unexpected regional variations in MTR asym values in femoral cartilage. By varying frequency of the saturation pulses in a range of 60 Hz, increased intensity and improved homogeneity of the MTR asym maps was achieved.

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