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Abstract #4233

Reproducibility of carnosine quantification in the calf muscle by 1H MRS at 7T and detection of its concentration changes following acute physical activity

Ivica Just Kukurova 1 , Barbara Ukropcov 2,3 , Marjeta Tuek Jelenc 1 , Milan Sedliak 4 , Marek Chmelik 1 , Jozef Ukropec 2 , Martin Krk 1,5 , Siegfried Trattnig 1 , and Ladislav Valkovič 1,6

1 High Field MR Centre, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, 2 Institute of Experimental Endocrinology, Slovak Academy of Sciences, Bratislava, Slovakia, 3 Faculty of Medicine, Comenius University, Bratislava, Slovakia, 4 Faculty of Physical Education and Sport, Comenius University, Bratislava, Slovakia, 5 Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria, 6 Institute of Measurement Science, Slovak Academy of Sciences, Bratislava, Slovakia

Reproducibility of carnosine measurement in the calf muscles was tested on 5 volunteers by STEAM sequence with very good results of CV (6.3% for SOL, 9.1% for GM). Effect of one hour running on carnosine concentration was examined on 7 volunteers, which did not prove to be significant. However, changes in the shape of the carnosine peak appeared, in form of its widening or splitting and also its shift. As carnosine is pH sensitive, we suppose it is a consequence of different use of carnosine buffering capacity in oxidative and glycolytic muscle fibres leading to different pH in these compartments.

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