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Abstract #4242

Dystrophic Skeletal Muscle 1 H 2 O T 2 Analyzed for Multiple Components

Sean C Forbes 1 , William T Triplett 1 , Rebecca Willcocks 1 , Abhinandan Batra 1 , Ravneet Vohra 1 , James Pollaro 2 , Dah-Jyuu Wang 3 , Richard Finkel 4 , Barry J Byrne 5 , Barry S Russman 6 , Erika Finanger 6 , Michael Daniels 7 , William Rooney 2 , Glenn A Walter 1 , H Lee Sweeney 8 , and Krista Vandenborne 1

1 University of Florida, Gainesvillle, Florida, United States, 2 Oregon Health & Science University, Oregon, United States, 3 The Children's Hospital of Philadelphia, Pennsylvania, United States, 4 Nemours Children's Hospital, Florida, United States, 5 University of Florida, Gainesville, Florida, United States, 6 Shriners Hospital, Oregon, United States, 7 University of Texas at Austin, Texas, United States, 8 University of Pennsylvania, Pennsylvania, United States

This study evaluated 1 H 2 O T 2 of skeletal muscle in boys with Duchenne muscular dystrophy (DMD) and unaffected controls, and in dystrophic mice before and after downhill running. Data were acquired using single voxel 1 H-MRS and analyzed for multiple components using non-negative least squares analyses (NNLS). NNLS revealed differences between dystrophic muscle and controls, including DMD having a more predominant long component. The long component was affected by corticosteroid treatment and downhill running in dystrophic muscle and was consistent with muscle damage/inflammation contributing to this component. Overall, NNLS analyses may provide valuable insight when interpreting 1 H 2 O T 2 changes in dystrophic muscle.

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