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Abstract #4272

Cross Sectional and Longitudinal Magnetisation transfer Ratio in Prion disease at 3 Tesla

Enrico De Vita 1,2 , Marie-Claire Porter 3,4 , Ivor Simpson 5 , Zoe Fox 6 , Gerard Ridgway 7 , Sebastien Ourselin 5 , Peter Rudge 3,4 , Diana Caine 3,4 , Rolf Jager 1,2 , Tarek Yousry 1,2 , John Collinge 3,4 , Simon Mead 3,4 , Harpreet Hyare 3,4 , and John S Thornton 1,2

1 Lysholm Department of Neuroradiology, National Hospital for Neurology and Neurosurgery, London, United Kingdom, 2 Academic Neuroradiological Unit, Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, London, United Kingdom, 3 MRC Prion Unit, Department of Neurodegenerative Diseases, UCL Institute of Neurology, London, United Kingdom, 4 National Prion Clinic, National Hospital for Neurology and Neurosurgery, London, United Kingdom, 5 Centre for Medical Image Computing, University College London, London, United Kingdom, 6 Education unit, UCL Institute of Neurology, London, United Kingdom, 7 Wellcome Trust Centre for Neuroimaging, UCL Institute of Neurology, London, United Kingdom

At 1.5T Magnetisation Transfer (MTR) correlated with clinical severity in inherited prion patients and was shown to be potentially more sensitive to structural changes than conventional imaging. We exploited the higher SNR available at 3T to further elucidate associations between regional cerebral MTR and disease progression in prion disease patients scanned serially (including sporadic, iatrogenic, variant forms alongside inherited). At baseline patients displayed lower MTR values in several ROIs vs controls; MTR correlated with clinical assessment (evaluated using the prion MRC score). MTR also decreased longitudinally and the rate of decrease correlated with rate of decrease of MRC score.

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