Meeting Banner
Abstract #4295

An Arterial Spin Labelling Study Revealing Altered Neurovascular Status in Idiopathic Parkinson's Disease; Comparisons with Cerebrovascular Disease

Sarah Al-Bachari 1 , Hedley Emsley 2 , Rishma Vidyasagar 1,3 , and Laura Parkes 4

1 Imaging, University of Manchester, Manchester, United Kingdom, 2 Neurology, Royal Preston Hospital, Preston, Lancashire, United Kingdom, 3 Department of Anatomy and Neurosciences, University of Melbourne,Victoria, Victoria, 3010, Australia, 4 Imaging, Manchester University, Manchester, United Kingdom

Idiopathic Parkinsons disease (IPD) is the second most common neurodegenerative disorder; vascular mechanisms are rapidly emerging as key players in the neurodegenerative process in preclinical studies, yet clinical studies remain equivocal. To investigate the neurovascular status in IPD we used arterial spin labelling (ASL) MRI techniques measuring cerebral blood flow (CBF) and arterial arrival time (AAT), comparing findings to patients with known cerebrovascular disease (CVD) and healthy controls. Results revealed a diffuse widespread increase in AAT in the IPD group compared to controls, which was similar to, but more pronounced than the prolongation of AAT seen in CVD, providing evidence of an alteration in neurovascular status.

This abstract and the presentation materials are available to members only; a login is required.

Join Here