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Abstract #4312

4D Flow MRI for intracranial hemodynamic assessment in Alzheimers Disease

Leonardo A Rivera-Rivera 1 , Patrick Turski 2 , Eric M Schrauben 1 , Phillip Kilgas 1 , Carson Hoffman 1 , Kevin M Johnson 1 , Michael Loecher 1 , Chuck Illingworth 2 , Sterling C Johnson 2 , and Oliver Wieben 1,3

1 Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, 2 Medicine, University of Wisconsin-Madison, WI, United States, 3 Radiology, University of Wisconsin-Madison, WI, United States

Cerebral arteries are often morphologically altered and dysfunctional in Alzheimers disease. In this study, 4D flow MRI was used to measure intra-cranial flow features, particularly mean flow and pulsatility index in patients with AD, MCI and in healthy controls. We found a statistically significant decrease in mean flow, and an increase in pulsatility index for the AD and MCI. With the large volume coverage and high temporal and spatial resolution, 4D flow MRI can provide additional biomarkers of vascular health that can contribute to the identifying patients who could benefit from interventions to improve circulatory system functions.

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