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Abstract #4314

Brain iron levels as measured by Quantitative Susceptibility Mapping (QSM) are not significantly different between subjects with Mild Cognitive Impairment (MCI) and controls

Jiri M.G. van Bergen 1 , Xu Li 2 , Michael Wyss 3 , Simon J. Schreiner 1 , Stefanie C. Steininger 1 , Jun Hua 2 , Roger Nitsch 1 , Klaas P. Pruessmann 3 , Peter C.M. van Zijl 2 , Marilyn S. Albert 4 , Christoph Hock 1 , and Paul G. Unschuld 1

1 Division of Psychiatry Research and Psychogeriatric Medicine, University of Zurich, Zurich, Zurich, Switzerland, 2 F.M. Kirby center for Functional Brain Imaging, Kennedy Krieger Institute and Johns Hopkins School of Medicine, Baltimore, Maryland, United States, 3 Institute for Biomedical Engineering, University of Zurich and ETH Zurich, Zurich, Switzerland, 4 Department of Neurology, Johns Hopkins School of Medicine, Baltimore, Maryland, United States

In this study it was shown that subjects with Mild Cognitive Impairment (MCI) do not have significantly different susceptibility values in the basal ganglia and the major cortical areas. Moreover, susceptibility values do not show strong correlations with structure volumes. Susceptibility in gray matter has been shown to relate to tissue iron content, which is known to be elevated in advanced stages of Alzheimers disease (AD). However, in these subjects with increased risk for late onset AD, our results suggest that susceptibility as a single measure cannot be used as a biomarker for brain dysfunction as reflected by cognitive impairment.

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