Abstract #4314
Brain iron levels as measured by Quantitative Susceptibility Mapping (QSM) are not significantly different between subjects with Mild Cognitive Impairment (MCI) and controls
Jiri M.G. van Bergen 1 , Xu Li 2 , Michael Wyss 3 , Simon J. Schreiner 1 , Stefanie C. Steininger 1 , Jun Hua 2 , Roger Nitsch 1 , Klaas P. Pruessmann 3 , Peter C.M. van Zijl 2 , Marilyn S. Albert 4 , Christoph Hock 1 , and Paul G. Unschuld 1
1
Division of Psychiatry Research and
Psychogeriatric Medicine, University of Zurich, Zurich,
Zurich, Switzerland,
2
F.M.
Kirby center for Functional Brain Imaging, Kennedy
Krieger Institute and Johns Hopkins School of Medicine,
Baltimore, Maryland, United States,
3
Institute
for Biomedical Engineering, University of Zurich and ETH
Zurich, Zurich, Switzerland,
4
Department
of Neurology, Johns Hopkins School of Medicine,
Baltimore, Maryland, United States
In this study it was shown that subjects with Mild
Cognitive Impairment (MCI) do not have significantly
different susceptibility values in the basal ganglia and
the major cortical areas. Moreover, susceptibility
values do not show strong correlations with structure
volumes. Susceptibility in gray matter has been shown to
relate to tissue iron content, which is known to be
elevated in advanced stages of Alzheimers disease (AD).
However, in these subjects with increased risk for late
onset AD, our results suggest that susceptibility as a
single measure cannot be used as a biomarker for brain
dysfunction as reflected by cognitive impairment.
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