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Abstract #4345

Comparison of QSM, T2-Relaxometry and T2-Weighted Imaging at 7T for Assessment of Basal Ganglia Iron in MS Patients

Petra Schmalbrock 1 , Mary Russell 1 , Grant K Yang 1 , Jacqueline A Nicholas 2 , Michael V Knopp 1 , and David Pitt 3

1 Radiology, The Ohio State University, Columbus, Ohio, United States, 2 Neurology, The Ohio State University, Columbus, Ohio, United States, 3 Neurology, Yale School of Medicine, New Haven, CT, United States

Basal ganglia iron was assessed in 29 MS patients using CSF-normalized T2-weighting, T2 relaxometry and QSM at 7T. All three methods produced similar results, most notably regional variability within the three analyzed structures (globus pallidus, putamen and caudate) was consistently seen with all methods. This variability has to be taken into account in future analysis and may relate to the functional anatomy of the basal ganglia.

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