Comparison of QSM, T2-Relaxometry and T2-Weighted Imaging at 7T for Assessment of Basal Ganglia Iron in MS Patients
Petra Schmalbrock 1 , Mary Russell 1 , Grant K Yang 1 , Jacqueline A Nicholas 2 , Michael V Knopp 1 , and David Pitt 3
Radiology, The Ohio State University,
Columbus, Ohio, United States,
The Ohio State University, Columbus, Ohio, United
Yale School of Medicine, New Haven, CT, United States
Basal ganglia iron was assessed in 29 MS patients using
CSF-normalized T2-weighting, T2 relaxometry and QSM at
7T. All three methods produced similar results, most
notably regional variability within the three analyzed
structures (globus pallidus, putamen and caudate) was
consistently seen with all methods. This variability has
to be taken into account in future analysis and may
relate to the functional anatomy of the basal ganglia.
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