Abstract #4351
Multi-contrast MRI of Myelination after Transplantation of Human Glial-Restricted Progenitor Cells in a Dysmyelinated Mouse Model
Antje Arnold 1,2 , Jiangyang Zhang 1,2 , Guanshu Liu 1,3 , Agatha Lyczek 1,2 , Miroslaw Janowski 1,4 , Jeff W.M. Bulte 1,2 , and Piotr Walczak 1,2
1
Dept. of Radiology and Radiological Science,
Johns Hopkins University School of Medicine, Baltimore,
Maryland, United States,
2
Cellular
Imaging Section, Institute for Cell Engineering,
Baltimore, Maryland, United States,
3
F.M.
Kirby Research Center for Functional Brain Imaging,
Kennedy Krieger Institute, Baltimore, Maryland, United
States,
4
NeuroRepair
Department, Polish Academy of Sciences, Warsaw, Poland
Recent advances in regenerative medicine raise hope that
the transplantation of human GRPs may be an effective
approach to restore brain function in patients who
suffer from myelin disorders. The detection of
remyelination is still quite challenging with
non-invasive MR imaging methods. The goal of our study
was to improve the utility of non-invasive MR imaging
for evaluation of myelination by human GRPs. Here we
show that T2-w and quantitative magnetization transfer
imaging revealed myelination after transplantation of
hGRPs in a dysmyelinated mouse model. However, diffusion
tensor imaging data did not show significant improvement
compared to non-transplant controls.
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