Abstract #4365
Magnetization Transfer from Inhomogeneously Broadened Lines (ihMT): Application on a mouse model of experimental autoimmune encephalomyelitis (EAE)
Valentin H. Prevost 1 , Angele Viola 1 , Olivier M. Girard 1 , Adriana T. Perles-Barbacaru 1 , Jennifer Tracz 1 , Gopal Varma 2 , David C. Alsop 2 , and Guillaume Duhamel 1
1
CRMBM CNRS UMR 7339, Aix-Marseille
University, Marseille, France,
2
Departement
of radiology, BIDMC, Harvard Medical School, Boston, MA,
United States
Inhomogeneous magnetization transfer (ihMT) imaging has
been recently proposed as new technique for myelin
imaging. Whereas it preclinical feasibility has been
demonstrated, it sensitivity for myelin disorders
pathology (e.g. multiple sclerosis (MS)) remains to be
assessed. The purpose of this study was to investigate
the sensitivity of ihMT for a murine model of
experimental autoimmune encephalomyelitis (EAE) induced
with the MOG peptide.
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