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Abstract #4365

Magnetization Transfer from Inhomogeneously Broadened Lines (ihMT): Application on a mouse model of experimental autoimmune encephalomyelitis (EAE)

Valentin H. Prevost 1 , Angele Viola 1 , Olivier M. Girard 1 , Adriana T. Perles-Barbacaru 1 , Jennifer Tracz 1 , Gopal Varma 2 , David C. Alsop 2 , and Guillaume Duhamel 1

1 CRMBM CNRS UMR 7339, Aix-Marseille University, Marseille, France, 2 Departement of radiology, BIDMC, Harvard Medical School, Boston, MA, United States

Inhomogeneous magnetization transfer (ihMT) imaging has been recently proposed as new technique for myelin imaging. Whereas it preclinical feasibility has been demonstrated, it sensitivity for myelin disorders pathology (e.g. multiple sclerosis (MS)) remains to be assessed. The purpose of this study was to investigate the sensitivity of ihMT for a murine model of experimental autoimmune encephalomyelitis (EAE) induced with the MOG peptide.

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