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Abstract #4368

Quantification of normal-appearing white matter in Multiple Sclerosis (MS) by quantitative susceptibility mapping (QSM)

Weiwei Chen 1 , Yan Zhang 1 , Wenzhen Zhu 1 , Ketao Mu 1 , Chu Pan 1 , Susan A. Gauthier 2 , and Yi Wang 3

1 Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science& Technology, Wuhan, Hubei, China, 2 Neurology, Weill Cornell Medical College, New York, United States, 3 Radiology, Weill Cornell Medical College, New York, United States

A total of 70 consecutive clinical confirmed MS patients and 26 age and gender matched healthy controls (HCs) who underwent quantitative susceptibility mapping (QSM) were retrospectively selected in this study to assess the susceptibility of NAWM and its correlation with MS lesions susceptibility variation and clinical features in MS patients. This study suggests the following findings. 1) The NAWM of MS patients showed significantly higher susceptibility than NWM of HCs. 2) The NAWM of patients with Gd-enhanced lesions showed a similar susceptibility to HCs NWM, while the NAWM of MS patients without Gd-enhanced lesions showed significantly higher susceptibility than both healthy controls NWM and the NAWM of patients with Gd-enhanced lesions. 3) The susceptibility of NAWM was positively correlated with the increase of MS lesions susceptibilities.

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