Abstract #4368
Quantification of normal-appearing white matter in Multiple Sclerosis (MS) by quantitative susceptibility mapping (QSM)
Weiwei Chen 1 , Yan Zhang 1 , Wenzhen Zhu 1 , Ketao Mu 1 , Chu Pan 1 , Susan A. Gauthier 2 , and Yi Wang 3
1
Radiology, Tongji Hospital, Tongji Medical
College, Huazhong University of Science& Technology,
Wuhan, Hubei, China,
2
Neurology,
Weill Cornell Medical College, New York, United States,
3
Radiology,
Weill Cornell Medical College, New York, United States
A total of 70 consecutive clinical confirmed MS patients
and 26 age and gender matched healthy controls (HCs) who
underwent quantitative susceptibility mapping (QSM) were
retrospectively selected in this study to assess the
susceptibility of NAWM and its correlation with MS
lesions susceptibility variation and clinical features
in MS patients. This study suggests the following
findings. 1) The NAWM of MS patients showed
significantly higher susceptibility than NWM of HCs. 2)
The NAWM of patients with Gd-enhanced lesions showed a
similar susceptibility to HCs NWM, while the NAWM of MS
patients without Gd-enhanced lesions showed
significantly higher susceptibility than both healthy
controls NWM and the NAWM of patients with Gd-enhanced
lesions. 3) The susceptibility of NAWM was positively
correlated with the increase of MS lesions
susceptibilities.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Click here for more information on becoming a member.
