Abstract #4379
Are there differences between macrocyclic gadolinium contrast agents for brain tumor imaging? Results of a Multicenter Intra-individual Crossover Comparison of Gadobutrol with Gadoteridol (The TRUTH study)
Martin P Smith 1 , Kenneth R Maravilla 2 , Stefano Bastianello 3 , Eva Bueltmann 4 , Toshinori Hirai 5 , Tiziano Frattini 6 , Cesare Colosimo 7 , and Gianpaolo Pirovano 8
1
Department of Radiology, Beth Israel
Deaconess Medical Center, Boston, MA, United States,
2
University
of Washington, WA, United States,
3
Neuroradiology
Department, University of Pavia, Pavia, Italy,
4
Oberartzin
Institut fur Diagnostiche und Interventionelle
Neuroradiologie, Hannover, Germany,
5
Kumamoto
University, Kumamoto, Japan,
6
Ospedale
Valduce, Como, Italy,
7
Policlinico
Agostino Gemelli, Rome, Italy,
8
Bracco
Diagnostics Inc., Monroe, NJ, United States
Two-hundred-twenty nine patients with suspected brain
tumors underwent two identical, randomized MRI exams at
1.5T; one enhanced with 0.1 mmol/kg gadoteridol
(ProHance) and the other with 0.1 mmol/kg gadobutrol
(Gadavist). Three blinded readers evaluated matched
image sets for qualitative (lesion extent, delineation,
morphology, enhancement, global preference) and
quantitative (LBR, % enhancement) lesion enhancement and
randomized, unmatched image sets for accuracy in lesion
diagnosis vs. final clinical diagnosis. No significant
differences were noted by any reader for any end-point.
The results confirm that the higher concentration of the
Gadavist formulation has no impact on routine
morphologic imaging of brain tumors.
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