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Abstract #4381

Differentiation of High-grade and Low-grade Diffuse Gliomas by Intravoxel Incoherent Motion MRI

Osamu Togao 1 , Akio Hiwatashi 1 , Koji Yamashita 1 , Kazufumi Kikuchi 1 , Marc Van Cauteren 2 , and Hiroshi Honda 1

1 Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Fukuoka, Japan, 2 Philips Electronics Japan, Tokyo, Japan

Intravoxel incoherent motion (IVIM) has been proposed as a method to measure diffusion and perfusion using a single diffusion-weighted acquisition scheme. The both diffusion and perfusion properties are major features in determining glioma grades. In this study, we prospectively evaluated the diagnostic performance of IVIM parameters in differentiating high-grade gliomas (HGGs) from low-grade gliomas (LGGs). Both true diffusion D and perfusion fracture f were useful in the differentiation, and f showed the best diagnostic performance. IVIM imaging can be used as a noninvasive quantitative imaging method in differentiating HGG from LGG.

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