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Abstract #4386

Towards imaging tumor cellularity: diffusion basis spectrum imaging (DBSI) and amide proton transfer (APT)

Chien-Yuan Eddy Lin 1,2 , Bing Wu 2 , Hung-Wen Kao 3,4 , Peng Sun 5 , Yong Wang 5 , and Sheng-Kwei Song 5

1 GE Healthcare, Taipei, Taiwan, 2 GE Healthcare China, Beijing, China, 3 Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, 4 Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei, Taiwan, 5 Department of Radiology, Washington University School of Medicine, St. Louis, MO, United States

Tumor cellularity is an important indicator of aggressiveness and the efficiency of chemotherapy. Amide proton transfer (APT) imaging detects the proton exchange between bulk water and the amide protons in endogenous mobile proteins and peptides. Previous studies demonstrated that APT grading of diffuse gliomas might reflect tumor cellularity. Recently, a newly developed diffusion basis spectrum imaging (DBSI) models tissue water diffusion as a linear combination of anisotropic and isotropic diffusion tensors4, allowing the quantification of restricted and non-restricted isotropic diffusion tensor components reflecting the extent of cellularity and edema respectively. The aim of this study was to assess changes in APT and DBSI metrics in conventional MRI identified brain tumors.

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