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Abstract #4404

Dynamic Susceptibility Contrast Perfusion Imaging Revealed Asymmetric Cerebral Blood Flow in Chronic TBI Patients

Wei Liu 1,2 , Jennifer Pacheco 1,2 , Cyrus Eierud 1,2 , David Joy 1,3 , Justin Senseney 1,2 , Ping-Hong Yeh 1,2 , Dominic Nathan 1,2 , Elyssa Sham 1,2 , John Ollinger 1,2 , Terrence Oakes 1,2 , and Gerard Riedy 1,2

1 National Intrepid Center of Excellence, Walter Reed National Military Medical Center, Bethesda, MD, United States, 2 National Capital Neuroimaging Consortium, Bethesda, MD, United States, 3 Center of Neuroscience and Regenerative Medicine, Bethesda, MD, United States

Cerebral perfusion of 204 chronic TBI patients from a military population was assessed using dynamic susceptibility contrast imaging. Mild and moderate TBI patients demonstrated unaltered regional cerebral blood flow (rCBF) in twelve subcortical ROIs compared to the 31 controls. Severe TBI patients demonstrated reduced rCBF in a couple regions. All three categories of the TBI patients demonstrated significantly increased asymmetric rCBF in the pallidum. However, the pallidum volume of the patients demonstrated similar right-left asymmetry compared to the controls. This increased asymmetric rCBF could be a compensatory mechanism to the reduced rCBF typically seen at the acute and subacute stage.

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