Abstract #4404
Dynamic Susceptibility Contrast Perfusion Imaging Revealed Asymmetric Cerebral Blood Flow in Chronic TBI Patients
Wei Liu 1,2 , Jennifer Pacheco 1,2 , Cyrus Eierud 1,2 , David Joy 1,3 , Justin Senseney 1,2 , Ping-Hong Yeh 1,2 , Dominic Nathan 1,2 , Elyssa Sham 1,2 , John Ollinger 1,2 , Terrence Oakes 1,2 , and Gerard Riedy 1,2
1
National Intrepid Center of Excellence,
Walter Reed National Military Medical Center, Bethesda,
MD, United States,
2
National
Capital Neuroimaging Consortium, Bethesda, MD, United
States,
3
Center
of Neuroscience and Regenerative Medicine, Bethesda, MD,
United States
Cerebral perfusion of 204 chronic TBI patients from a
military population was assessed using dynamic
susceptibility contrast imaging. Mild and moderate TBI
patients demonstrated unaltered regional cerebral blood
flow (rCBF) in twelve subcortical ROIs compared to the
31 controls. Severe TBI patients demonstrated reduced
rCBF in a couple regions. All three categories of the
TBI patients demonstrated significantly increased
asymmetric rCBF in the pallidum. However, the pallidum
volume of the patients demonstrated similar right-left
asymmetry compared to the controls. This increased
asymmetric rCBF could be a compensatory mechanism to the
reduced rCBF typically seen at the acute and subacute
stage.
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