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Abstract #4414

Multiparametric MRI characterization of mild traumatic brain injury in mice

Yichu Liu 1,2 , Lora Watts 1 , Qiang Shen 1 , Hemanth Manga 1,2 , and Timothy Duong 1

1 Research Imaging Center, University of Texas Health Science Center, San Antonio, Texas, United States, 2 Biomedical Engineering, UT San Antonio, San Antonio, Texas, United States

The goal of this study was to use multiparametric MRI (T2, CBF, ADC, and FA) to longitudinally characterize the spatiotemporal dynamics during hyperacute and subacute mild traumatic brain injury (TBI) in mice. The impact was targeted to the left primary forelimb somatosensory cortex. Comparisons were made with functional assessment measured by the forelimb asymmetry test. Moreover, comparisons were also made with published rat mild TBI data under essentially

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