Abstract #4416
White Matter Abnormalities in Acute Mild Traumatic Brain Injury: A Diffusion Kurtosis MRI Study
Sohae Chung 1,2 , Els Fieremans 1,2 , Jelle Veraart 1,2 , Dmitry S. Novikov 1,2 , Jacqueline Smith 1,2 , Steven R. Flanagan 3 , and Yvonne W. Lui 1,2
1
Center for Advanced Imaging Innovation and
Research (CAI2R), Department of Radiology, New York
University School of Medicine, New York, NY, United
States,
2
Bernard
and Irene Schwartz Center for Biomedical Imaging,
Department of Radiology, New York University School of
Medicine, New York, NY, United States,
3
Department
of Rehabilitation Medicine, New York University Langone
Medical Center, New York, NY, United States
Mild traumatic brain injury (mTBI) is a growing public
health problem; however, overall sensitivity to white
matter (WM) injury and understanding of the underlying
pathophysiology is limited. Here, we investigate WM
abnormalities in mTBI by using WM diffusion metrics, as
derived from DKI with a two-compartment model. Using
TBSS and ROI analyses, we demonstrate that there are
several metrics that are sensitive to injury after mTBI,
suggesting that increased restrictions along the axons,
both inside and outside, such as possibly axonal
beading, could occur acutely after injury. This provides
unique insight into the underlying mechanisms of WM
alterations after mTBI.
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