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Abstract #4423

Multi-parameter mapping of the human cervical spinal cord in brachial plexus root implantation

Rebecca Sara Samson 1 , Carolina Kachramanoglou 1 , David Choi 2 , Antoine Lutti 3 , David L Thomas 4 , Nikolaus Weiskopf 3 , Olga Ciccarelli 5,6 , and Claudia A M Wheeler-Kingshott 1

1 NMR Research Unit, Department of Neuroinflammation, Queen Square MS Centre, UCL Institute of Neurology, London, England, United Kingdom, 2 Spinal Repair Unit, UCL Institute of Neurology, London, England, United Kingdom, 3 Wellcome Trust Centre for Neuroimaging, UCL Institute of Neurology, London, England, United Kingdom, 4 5Neuroradiological Academic Unit, Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, London, England, United Kingdom, 5 NMR Research Unit, Department of Brain Repair and Rehabilitation, Queen Square MS Centre, UCL Institute of Neurology, London, England, United Kingdom, 6 6NIHR UCL/UCLH Biomedical Research Centre (BRC), London, England, United Kingdom

Brachial plexus avulsion (BPA) may lead to paralysis and anaesthetic of the corresponding arm. Re-implantation of avulsed ventral roots is an effective surgical technique that leads to improved motor recovery. The development of quantitative MRI methods to assess spinal cord tissue structure following BPA may provide sensitive non-invasive markers for therapy monitoring. We aimed to assess whether multi-parameter mapping of the upper cervical cord (i.e., above the site of injury) detects pathological changes in patients with BPA who have received re-implantation, when compared with healthy subjects. In patients, the relationship between measured quantitative parameters and clinical outcome measures is explored.

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