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Abstract #4432

CEST of the Cervical Spinal Cord at 7 Tesla

Adrienne Dula 1 , Siddharama Pawate 1 , Lindsey M Dethrage 1 , Benjamin N Conrad 1 , Robert L Barry 1 , and Seth A Smith 1

1 Vanderbilt University, Nashville, Tennessee, United States

Optimal CEST saturation parameters found via simulation were implemented for CEST MRI in ten healthy controls and ten MS patients and results were examined using traditional asymmetry analysis and Lorentzian fit method. Distinct spectral features for all tissue types studied were found both up- and down-field from the water resonance. The z-spectra in healthy subjects had the expected z-spectra shape with CEST effects apparent from 2.0 ppm 4.5 ppm while the z-spectra from MS patients demonstrated deviations from this expected, normal shape indicating this methods sensitivity to known pathology as well as those tissues appearing normal on conventional MRI.

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