Abstract #4438
Comparison of white matter damage progression in dislocation versus contusion injury in rat spinal cord using longitudinal diffusivity measurements
Andrew C.H. Yung 1 , Stephen Mattucci 2 , Barry Bohnet 1 , Jie Liu 2 , Wolfram Tetzlaff 2 , Piotr Kozlowski 1 , and Thomas Oxland 2
1
UBC MRI Research Centre, University of
British Columbia, Vancouver, BC, Canada,
2
ICORD,
Vancouver, BC, Canada
We assessed the ability of ex vivo longitudinal
diffusivity (Dlong) to differentiate between two injury
mechanisms of rat SCI (standard contusion model and a
novel dislocation model) at various time points after
injury (3 hours, 24 hours, 7 days). Regional white
matter Dlong averages (dorsal, lateral, ventral) were
compared along the rostrocaudal extent of the cord. The
observed spatial patterns in Dlong were distinctly
different between the injury models; in particular, the
dislocation model showed a greater reduction in Dlong in
the lateral white matter as compared to the dorsal white
matter Dlong, and vice-versa for the contusion model.
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