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Abstract #4438

Comparison of white matter damage progression in dislocation versus contusion injury in rat spinal cord using longitudinal diffusivity measurements

Andrew C.H. Yung 1 , Stephen Mattucci 2 , Barry Bohnet 1 , Jie Liu 2 , Wolfram Tetzlaff 2 , Piotr Kozlowski 1 , and Thomas Oxland 2

1 UBC MRI Research Centre, University of British Columbia, Vancouver, BC, Canada, 2 ICORD, Vancouver, BC, Canada

We assessed the ability of ex vivo longitudinal diffusivity (Dlong) to differentiate between two injury mechanisms of rat SCI (standard contusion model and a novel dislocation model) at various time points after injury (3 hours, 24 hours, 7 days). Regional white matter Dlong averages (dorsal, lateral, ventral) were compared along the rostrocaudal extent of the cord. The observed spatial patterns in Dlong were distinctly different between the injury models; in particular, the dislocation model showed a greater reduction in Dlong in the lateral white matter as compared to the dorsal white matter Dlong, and vice-versa for the contusion model.

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