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Abstract #4461

The Accuracy of Quantitative MR Elastography in an Anatomically Accurate Diastolic Cardiac Phantom

Arvin Arani 1 , Shivaram Poigai Arunachalam 1 , Phillip Rossman 1 , Armando Manduca 2 , David S. Lake 1 , Joshua D. Trzasko 1 , Kiaran P. McGee 1 , Kevin J Glaser 1 , Richard L. Ehman 1 , and Philip Araoz 1

1 Radiology, Mayo Clinic, Rochester, Minnesota, United States, 2 Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States

Normal cardiac function is dependent on the mechanical properties of the myocardium, which may serve as a valuable predictor of disease. Several groups have investigated the use of MR Elastography to measure stiffness in vivo. However, a thorough evaluation of the accuracy of the reported stiffness measurements and the optimal experimental settings has not been well established. The purpose of this work, was to evaluate the accuracy of 3D MRE direct inversion at multiple frequencies, on curl wave fields in a morphologically accurate left ventricular phantom using dynamic mechanical testing (DMA) as the reference standard.

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