Heterogeneity of Myocardial ATP Flux Rate via CK In Vivo Porcine Hearts with hiPSC Tri-lineage Cell Transplantation Using 2D CSI P-31 MR Spectroscopy

We investigated the functional impact of combined intramyocardial transplantation of cardiomyocytes, endothelial cells, and smooth muscle cells derived from hiPSCs to a porcine model of ischemia reperfusion (I/R). It was demonstrated that ATP turnover rate could be measured with two components, the creatine reaction rate and ATP hydrolysis rate, even without measuring Pi levels. MI injury has a heterogeneous effect on myocardial bioenergetics. The border zone PCr/ATP ratio is improved in the cell treated group compared with open patch group. The Kpcr ATP in the border zone is slightly increased in cell treated group compared with patch only group.

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