Abstract #4519
Effect of BOLD Contrast on Myocardial Registration
Ilkay Oksuz 1 , Anirban Mukhopadhyay 1 , Marco Bevilacqua 1 , Hsin-Jung Yang 2,3 , Rohan Dharmakumar 2,3 , and Sotirios A. Tsaftaris 1,4
1
IMT Institute for Advanced Studies, Lucca,
Tuscany, Italy,
2
Biomedical
Research Institute, Cedars Sinai Medical Center, Los
Angeles, California, United States,
3
Medicine,
University of California, Los Angeles, California,
United States,
4
Electrical
Engineering and Computer Science, Northwestern
University, Illinois, United States
Cardiac phase-resolved Blood-Oxygen-Level-Dependent
(CP-BOLD) MRI is a new approach for detecting ischemia
at rest. Currently disease assessment relies on
segmental analysis and uses only a few images in the
phase-resolved acquisition. It is expected that using
all phases can permit pixel-level characterization of
CP-BOLD MRI. In this study, state-of-the-art image
registration techniques are evaluated on cardiac BOLD
MRI data for the first time. The results show that
cardiac phase-dependent variations in myocardial BOLD
contrast in CP-BOLD images creates a statistically
significant decrease in the accuracy compared to
standard Cine MR images acquired under conditions of
health and myocardial ischemia.
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