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Abstract #4519

Effect of BOLD Contrast on Myocardial Registration

Ilkay Oksuz 1 , Anirban Mukhopadhyay 1 , Marco Bevilacqua 1 , Hsin-Jung Yang 2,3 , Rohan Dharmakumar 2,3 , and Sotirios A. Tsaftaris 1,4

1 IMT Institute for Advanced Studies, Lucca, Tuscany, Italy, 2 Biomedical Research Institute, Cedars Sinai Medical Center, Los Angeles, California, United States, 3 Medicine, University of California, Los Angeles, California, United States, 4 Electrical Engineering and Computer Science, Northwestern University, Illinois, United States

Cardiac phase-resolved Blood-Oxygen-Level-Dependent (CP-BOLD) MRI is a new approach for detecting ischemia at rest. Currently disease assessment relies on segmental analysis and uses only a few images in the phase-resolved acquisition. It is expected that using all phases can permit pixel-level characterization of CP-BOLD MRI. In this study, state-of-the-art image registration techniques are evaluated on cardiac BOLD MRI data for the first time. The results show that cardiac phase-dependent variations in myocardial BOLD contrast in CP-BOLD images creates a statistically significant decrease in the accuracy compared to standard Cine MR images acquired under conditions of health and myocardial ischemia.

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