Abstract #0006

Can the Stretched Exponential Model of Gas Diffusion Provide Clinically -Relevant Parenchyma Measurements of Lung Disease?

Alexei Ouriadov¹, Eric Lessard¹, David G McCormack², and Grace Parraga¹

¹Robarts Research Institute, The University of Western Ontario, London, ON, Canada, ²Department of Medicine, The University of Western Ontario, London, ON, Canada

We hypothesized that using inhaled noble gas MRI diffusion-weighted imaging, the diffusion scale estimated using the stretched exponential model would be strongly related to MRI estimates of the mean linear intercept of the lung parenchyma. In this proof-of-concept evaluation, we evaluated 34 never- and ex-smokers and compared parenchyma morphological estimates acquired using two different MRI approaches ad as well with CT and pulmonary function test measurements of acinar duct structure and function. This is important because in obstructive lung disease, the non-invasive measurement of parenchyma tissue destruction or maldevelopment may serve as a therapeutic target.

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