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Abstract #0019

Indirectly-Detected and Spin-Amplified Heteronuclear MRS and MRI

Chencai Wang1, Chaohsiung Hsu1, Stephanie Wolohan1, and Yung-Ya Lin1

1Department of Chemistry and Biochemistry, UCLA, Los Angeles, CA, United States

A general indirect-detection and spin-amplification scheme has been developed to enhance the sensitivity of heteronuclear MRS and MRI based on dynamic instability of the solvent proton magnetization under collective feedback fields of radiation damping and the distant dipolar field. The heteronuclear solute spins are first detected by the solvent proton spins through various magnetization transfer mechanisms and serve as small “input” signals to perturb the solvent proton magnetization, which is prepared in an unstable state. The weakly detected signal is then amplified through subsequent nonlinear evolution of the solvent proton magnetization to achieve 10x SNR improvement for 13C MRS and MRI.

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