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Abstract #0028

Imaging Whole Mouse Brain Cytoarchitecture by Quantitative Susceptibility Mapping at 10-μm Resolution

Hongjiang Wei1, Luke Xie2, Russell Dibb3, Wei Li4, Kyle Decker3, G. Allan Johnson3,5, and Chunlei Liu1,5

1Brain Imaging and Analysis Center, Duke University, Durham, NC, United States, 2Utah Center for Advanced Imaging Research, Department of Radiology, University of Utah, Salt Lake City, UT, United States, 3Center for In Vivo Microscopy, Duke University, Durham, NC, United States, 4Research Imaging Institute, University of Texas Health Science Center, San Antonio, TX, United States, 5Department of Radiology, School of Medicine, Duke University, Durham, NC, United States

In this study, we demonstrate that whole brain cytoarchitecture can be revealed by QSM at 10-μm resolution at 9.4T. Using QSM, we are able to reveal exquisite anatomical details such as retina layers of the eyeball, glomeruli in olfactory bulb, barrel cortex, medium-sized spiny neurons in striatum, cell layers of cerebellum, and hippocampus. This ultra-high resolution QSM of the intact mouse brain is a powerful dataset to allow analysis and visualization of the brain cytoarchitecture in 3D.

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