Abstract #0028

Imaging Whole Mouse Brain Cytoarchitecture by Quantitative Susceptibility Mapping at 10-μm Resolution

Hongjiang Wei¹, Luke Xie², Russell Dibb³, Wei Li⁴, Kyle Decker³, G. Allan Johnson^3,5, and Chunlei Liu^1,5

¹Brain Imaging and Analysis Center, Duke University, Durham, NC, United States, ²Utah Center for Advanced Imaging Research, Department of Radiology, University of Utah, Salt Lake City, UT, United States, ³Center for In Vivo Microscopy, Duke University, Durham, NC, United States, ⁴Research Imaging Institute, University of Texas Health Science Center, San Antonio, TX, United States, ⁵Department of Radiology, School of Medicine, Duke University, Durham, NC, United States

In this study, we demonstrate that whole brain cytoarchitecture can be revealed by QSM at 10-μm resolution at 9.4T. Using QSM, we are able to reveal exquisite anatomical details such as retina layers of the eyeball, glomeruli in olfactory bulb, barrel cortex, medium-sized spiny neurons in striatum, cell layers of cerebellum, and hippocampus. This ultra-high resolution QSM of the intact mouse brain is a powerful dataset to allow analysis and visualization of the brain cytoarchitecture in 3D.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.