Abstract #0068

Effect of temporal resolution and serial autocorrelations in fast fMRI

Ashish Kaul Sahib¹, Klaus Mathiak², Michael Erb¹, Adham Elshahabi³, Silke Klamer³, Klaus Scheffler⁴, Niels Focke³, and Thomas Ethofer¹

¹Biomedical magnetic resonance, University of tuebingen, Tuebingen, Germany, ²5Department of Psychiatry, Psychotherapy and Psychosomatics, University Hospital Aachen, Aachen, Germany, ³Department of Neurology/Epileptology, University of tuebingen, Tuebingen, Germany, ⁴Max-Planck-Institute for Biological Cybernetics, Tuebingen, Germany

To assess the impact of colored noise on statistics and determine optimal imaging parameters in event-related fMRI (visual stimulation using checkerboards) acquired by simultaneous multi-slice imaging enabling repetition times (TR) between 2.64 to 0.26s. Optimal statistical power was obtained for a TR of 0.33s, but short TRs required higher-order autoregressive (AR) models to achieve stable statistics. Colored noise in event-related fMRI obtained at short TRs calls for more sophisticated correction of serial autocorrelations.

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