Abstract #0076

Incorporation of Finite Pulse Correction for Improved MT-Corrected Multicomponent T2 analysis of Cartilage

Fang Liu¹, Alexey Samsonov¹, Wally Block², and Richard Kijowski¹

¹Department of Radiology, University of Wisconsin-Madison, Madison, WI, United States, ²Department of Medical Physics, University of Wisconsin-Madison, Madison, WI, United States

Nuclear magnetic resonance studies have identified multiple water components within cartilage tissue. Previous studies using steady-state sequences based rapid method such as mcDESPOT and mcRISE have shown feasibility of multicomponent T2 analysis of cartilage. However, steady-state signal can be influenced by the finite pulse effect which might lead to biased parameter estimation. In this study, we incorporated the finite pulse correction in the mcRISE model and demonstrated the potential MT and finite pulse effect in-sensitive T2 parameters for multicomponent cartilage relaxometry analysis.

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