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Abstract #0130

Intracellular-extracellular water exchange as a biomarker of tumor response to stereotactic radiosurgery

Hatef Mehrabian1,2, Kimberly L Desmond3, Arjun Sahgal1,4, Hany Soliman1,4, Anne L Martel1,2, and Greg J Stanisz1,2

1Physical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada, 2Medical Biophysics, University of Toronto, Toronto, ON, Canada, 3Medical Physics and Applied Radiation Sciences, McMaster University, Hamilton, ON, Canada, 4Radiation Oncology, Odette Cancer Centre, Toronto, ON, Canada

Targeted radiation treatments are expected to induce DNA damage in tumor cells which leads to apoptosis. Apoptotic cells experience an increase in cell membrane permeability and surface-to-volume ratio, both of which result in increased water exchange rate between intracellular and extracellular compartments.

Using a three compartment relaxation model we demonstrate that early changes in intracellular-extracellular water exchange correlated well with tumor volume change one-month post-treatment. Moreover, when the water exchange rate was combined with early tumor volume change and was employed in a classifier, the patients with partial response and progressing disease could be identified with a very high accuracy.

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