Abstract #0140

Detection of myocardial infarcts without contrast agent injection: Comparison of spin-lock with magnetization transfer MR imaging

Joep van Oorschot¹, Martijn Froeling¹, Thijs van den Broek², Frebus van Slochteren², Steven Chamuleau², Peter Luijten¹, Tim Leiner¹, and Jaco Zwanenburg¹

¹Radiology, University Medical Center Utrecht, Utrecht, Netherlands, ²Cardiology, University Medical Center Utrecht, Utrecht, Netherlands

Two promising techniques for endogenous myocardial infarct detection are Magnetization Transfer and T1ρ-MRI. Goal of the study was to compare the ability to detect and quantify myocardial scar tissue in a chronic infarct model using MT and T1ρ mapping. In vivo MRI was performed on a clinical 1.5 MR scanner in 3 anesthetized pigs, 4 weeks after 90 minutes occlusion of the LAD. The MTR was significantly lower in the infarcted region (0.27±0.01 ms), compared to remote myocardium (0.38±0.01 ms).The T1ρ relaxation time was significantly higher in the infarcted region (87.0±1 ms), compared to healthy remote myocardium (56.4± 1 ms).

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