Joep van Oorschot1, Martijn Froeling1, Thijs van den Broek2, Frebus van Slochteren2, Steven Chamuleau2, Peter Luijten1, Tim Leiner1, and Jaco Zwanenburg1
1Radiology, University Medical Center Utrecht, Utrecht, Netherlands, 2Cardiology, University Medical Center Utrecht, Utrecht, Netherlands
Two promising techniques for endogenous
myocardial infarct detection are Magnetization Transfer and T1ρ-MRI. Goal of the study was
to compare the ability to detect and quantify myocardial scar tissue in a
chronic infarct model using MT and T1ρ mapping. In vivo MRI
was performed on a clinical 1.5 MR scanner in 3 anesthetized pigs, 4 weeks
after 90 minutes occlusion of the LAD. The MTR was
significantly lower in the infarcted region (0.27±0.01 ms), compared to remote
myocardium (0.38±0.01 ms).The T1ρ relaxation time was significantly
higher in the infarcted region (87.0±1 ms), compared to healthy remote
myocardium (56.4± 1 ms).
