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Abstract #0140

Detection of myocardial infarcts without contrast agent injection: Comparison of spin-lock with magnetization transfer MR imaging

Joep van Oorschot1, Martijn Froeling1, Thijs van den Broek2, Frebus van Slochteren2, Steven Chamuleau2, Peter Luijten1, Tim Leiner1, and Jaco Zwanenburg1

1Radiology, University Medical Center Utrecht, Utrecht, Netherlands, 2Cardiology, University Medical Center Utrecht, Utrecht, Netherlands

Two promising techniques for endogenous myocardial infarct detection are Magnetization Transfer and T1ρ-MRI. Goal of the study was to compare the ability to detect and quantify myocardial scar tissue in a chronic infarct model using MT and T1ρ mapping. In vivo MRI was performed on a clinical 1.5 MR scanner in 3 anesthetized pigs, 4 weeks after 90 minutes occlusion of the LAD. The MTR was significantly lower in the infarcted region (0.27±0.01 ms), compared to remote myocardium (0.38±0.01 ms).The T1ρ relaxation time was significantly higher in the infarcted region (87.0±1 ms), compared to healthy remote myocardium (56.4± 1 ms).

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