Meeting Banner
Abstract #0144

Elevated Hemoglobin A1c(HbA1c) Is Independently Associated with Large Lipid-Rich Necrotic Cores in Hypertensive Patients with Symptomatic Carotid Atherosclerosis: A 3.0T MRI Study

Huilin Zhao1, Beibei Sun1, Xiaosheng Liu1, Xihai Zhao2, Yongming Dai3, Chun Yuan4, and Jianrong Xu1

1Radiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, People's Republic of, 2Center for Biomedical Imaging Research, Tsinghua University School of Medicine, Beijing, China, People's Republic of, 3Philips Healthcare, Shanghai, China, People's Republic of, 4Radiology, University of Washington, Seattle, WA, United States

Further understanding of the association of hemoglobin A1c(HbA1c) levels with symptomatic carotid plaque characteristics will be helpful for stroke risk stratification and treatment strategy modification. This study sought to investigate the associations of HbA1c levels with MR-identified carotid plaque characteristics in hypertensive patients with acute stroke. Our key findings are that elevated HbA1c was associated with carotid plaque presence, higher HbA1c level tended to exhibit an increased plaque burden and larger lipid-rich necrotic core, independent of other cardiovascular risk factors. Our findings indicate that elevated HbA1c may contribute to the development of advanced carotid plaques in stroke patients with hypertension.

This abstract and the presentation materials are available to members only; a login is required.

Join Here