Abstract #0181

31P-MRS and MRI of lower leg muscle oxidative metabolism in heart failure patients

Ding Xia¹, Stuart D. Katz², and Ravinder R. Regatte¹

¹Center for Biomedical Imaging, Department of Radiology, New York University Langone Medical Center, New York, NY, United States, ²Division of Cardiology, Department of Medicine, New York University Langone Medical Center, New York, NY, United States

We measured the lower leg muscle oxidative metabolism in healthy volunteers (n=5) and heart failure patients (n=6) with quantitative ³¹P-MRS and MRI at 3T clinical scanner. The post-exercise rate of phosphocreatine (PCr) resynthesis was decreased in heart failure subjects (i.e. delayed PCr recovery time) compared to healthy volunteers in global calf muscle, as well as in predominantly fast twitch (type II) gastrocnemius muscle (medial and lateral, GM and GL) and predominantly slow twitch (type I) soleus (SOL) muscle.

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