Abstract #0187

CEST Metrics for Assessing Early Response to Stereotactic Radiosurgery in Human Brain Metastases

Kimberly L. Desmond^1,2, Hatef Mehrabian^1,2, Arjun Sahgal^1,3, Hany Soliman^1,3, and Greg J. Stanisz^1,2

¹Physical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada, ²Medical Biophysics, University of Toronto, Toronto, ON, Canada, ³Radiation Oncology, Odette Cancer Centre, Toronto, ON, Canada

Chemical exchange saturation transfer (CEST) spectra were collected at three timepoints following stereotactic radiosurgery (SRS). The magnetization transfer ratio (MTR) and CEST peak properties were evaluated at the offset frequencies of the NOE, amide and amine pools in the lesion and in the surrounding tissue. Positive correlation was found between changes in NOE peak amplitude and amide MTR at 1 week post-therapy and tumour volume change at one month post-therapy, while negative correlation was found between amide peak width and NOE peak amplitude at the pre-treatment timepoint with volume change at one month post-therapy (p<0.1).

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.